Group B coxsackieviruses readily establish persistent infections in human lymphoid cell lines

Authors:
  • DMD Matteucci
    D Matteucci
  • MPM Paglianti
    M Paglianti
  • AGA M Giangregorio
    A M Giangregorio
  • MCM R Capobianchi
    M R Capobianchi
  • FDF Dianzani
    F Dianzani
  • MBM Bendinelli
    M Bendinelli

Abstract
Exposing human lymphoid cell lines to uncloned or recently cloned group B coxsackieviruses results in the frequent establishment of chronically infected cultures. Persistence is maintained by a carrier culture mechanism involving virus spread through the medium and replication among a minority of cells at any given time. These studies provide a model for persistence by highly cytocidal viruses.

This publication has 15 references indexed in Scilit: