Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress
Open Access
- 2 March 2017
- journal article
- review article
- Published by MDPI AG in Antioxidants
- Vol. 6 (1) , 18
Abstract
Other than genetic regulation of salt sensitivity of blood pressure, many factors have been shown to regulate renal sodium handling which contributes to long-term blood pressure regulation and have been extensively reviewed. Here we present our progress on the Na/K-ATPase signaling mediated sodium reabsorption in renal proximal tubules, from cardiotonic steroids-mediated to reactive oxygen species (ROS)-mediated Na/K-ATPase signaling that contributes to experimental salt sensitivity.Keywords
Funding Information
- National Institutes of Health (R15 1R15DK106666-01A1, RO1 HL071556)
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