Asymmetric Intermolecular Pauson−Khand Reaction of Symmetrically Substituted Alkynes
Authors:
- 9 September 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 11 (19) , 4346-4349
Abstract
The asymmetric intermolecular Pauson-Khand reaction of symmetric alkynes has been accomplished for the first time. N-Phosphino-p-tolylsulfinamide (PNSO) ligands have been identified as efficient ligands in this process. The chirality of the cobalt S-bonded sulfinyl moiety was found to direct olefin insertion into one of the two possible cobalt-carbon bonds in the alkyne complex. Reaction of symmetric alkynes allows for a simplified experimental protocol since there is no need for separation of diastereomeric complexes.Keywords
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