SUMO: a novel target for anti-coronavirus therapy
Author:
- 26 March 2021
- journal article
- other
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 115 (5) , 292-299
Abstract
Over the past 20 years, humankind has encountered three severe coronavirus outbreaks. Currently ongoing, COVID-19 (coronavirus disease 2019) was declared a pandemic due to its massive impact on global health and the economy. Numerous scientists are working to identify efficacious therapeutic agents for COVID-19, although treatment ability has yet to be demonstrated. The SUMO (small ubiquitin-like modifier) system has diverse roles in viral manipulation, but the function of SUMO in coronaviruses is still unknown. The objective of this review article is to present recently published data suggesting contributions of the host SUMO system to coronavirus infection. These findings underscore the potential of SUMO as a novel target for anti-coronavirus therapy, and the need for a deeper understanding of coronavirus pathology to prepare and prevail against the current and emerging coronavirus outbreaks.Keywords
Funding Information
- National Research Foundation of Korea (NRF) grant funded by the Korean
- National Research Foundation of Korea (2020R1C1C1009367)
This publication has 77 references indexed in Scilit:
- Function and regulation of SUMO proteasesNature Reviews Molecular Cell Biology, 2012
- Epstein-Barr Virus Latent Membrane Protein 1 Regulates the Function of Interferon Regulatory Factor 7 by Inducing Its SumoylationJournal of Virology, 2012
- SUMO Binding by the Epstein-Barr Virus Protein Kinase BGLF4 Is Crucial for BGLF4 FunctionJournal of Virology, 2012
- Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) C-Terminal-Activating Region 3 Contributes to LMP1-Mediated Cellular Migration via Its Interaction with Ubc9Journal of Virology, 2011
- HPV E6 proteins target Ubc9, the SUMO conjugating enzymeVirus Research, 2011
- Modification of Nonstructural Protein 1 of Influenza A Virus by SUMO1Journal of Virology, 2011
- Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species TransmissionJournal of Virology, 2010
- Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene ExpressionJournal of Biological Chemistry, 2008
- Modification of papillomavirus E2 proteins by the small ubiquitin-like modifier family members (SUMOs)Virology, 2008
- Targeting SUMO E1 to Ubiquitin LigasesJournal of Biological Chemistry, 2007