Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch
- 7 January 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Reaction Chemistry & Engineering
- Vol. 6 (3) , 486-493
Abstract
An efficient and scalable enone-promoted method for the decarboxylation of trans-4-hydroxy-proline has been developed in flow to provide access to (R)-pyrrolidin-3-ol hydrochloride using biomass-derived isophorone. The advantages of deploying flow in this setting were reinforced by direct comparsion to batch. This method lays a foundation for fossil fuel and ammonia free alternative access to amines on scales relevant to manufacturing.Keywords
Funding Information
- Australian Research Council
- University of Queensland
- University of Melbourne
- Commonwealth Scientific and Industrial Research Organisation
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