LIMBIC SYSTEM IN ALZHEIMERS DISEASE - NEUROPATHOLOGIC INVESTIGATION

Authors:
  • MHM. W. Hopper
    M. W. Hopper
  • FVF. S. Vogel
    F. S. Vogel
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  • 1 January 1976
    • journal article
    • research article
Abstract
The morphologic alterations of Alzheimer''s disease, presenile and senile dementia, are conventionally associated with the cerebral cortex; it is clear that other areas of the brain, notably the hippocampus and amygdala, are involved as well. These structures, together with others such as the fornix, cingulate gyrus, septal nuclei and mamillary bodies, constitute the limbic system, which has been recognized as the anatomic substrate of memory, emotion and learning. Disturbances in these modalities are central to the clinical expression of Alzheimer''s disease; the limbic system was studied in its entirety in 9 patients with Alzheimer''s disease and in 3 elderly individuals with Down''s syndrome, in whom identical morphologic lesions were present. The limbic system was regularly involved in Alzheimer''s disease, to a severe degree and in a distinctively patterned distribution.

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