PROTEIN-QUALITY IN FEEDING LOW-BIRTH-WEIGHT INFANTS - A COMPARISON OF WHEY-PREDOMINANT VERSUS CASEIN-PREDOMINANT FORMULAS

Authors:
  • SKS KASHYAP
    S KASHYAP
  • EOE OKAMOTO
    E OKAMOTO
  • SKS KANAYA
    S KANAYA
  • KAK ABILDSKOV
    K ABILDSKOV
  • RDRB DELL
    RB DELL
  • WHWC HEIRD
    WC HEIRD
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  • 1 May 1987
    • journal article
    • research article
    • Vol. 79  (5) , 748-755
    • PMID:3575033
Abstract
Growth (.DELTA.weight, .DELTA.length, .DELTA.head circumference, and .DELTA.skinfold thickness), nitrogen retention, and chemical indices of metabolic tolerance (BUN concentration and acid-base status; plasma amino acid concentrations including free and bound cyst(e)ine; urinary excretion of sulfur amino acids) were determined serially in low birth weight infants (900 to 1,750 g) fed formulas differing only in protein quality. One contained unmodified bovine milk protein (a ratio of whey proteins to caseins of 18:82); the other contained modified bovine milk protein (a ratio of whey proteins to caseins of 60:40). Both provided protein and energy intakes, respectively, of approximately 3.4 g/kg/d and 120 kcal/kg/d. Neither weight gain nor the rate of increase in length, head circumference, and skinfold thickness differed between the two groups. Nitrogen retention of the two groups also did not differ. Although BN concentration and blood acid-base status did not differ, there were differences in the plasma concentrations of some amino acids. Plasma tyrosine concentration was higher in infants fed the casein-predominant protein, and plasma threonine concentration was higher in infants fed the whey-predominant protein. Neither plasma-free nor bound cyst(e)ine concentration differed between the two groups, but the greater cyst(e)ine intake of the whey-predominant group resulted in greater cyst(e)ine retention; this was accompanied by greater urinary taurine excretion, a reflection of greater taurine stores.

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