Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent
Open Access
- 1 August 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 49 (76) , 8522-8524
Abstract
The bi-functional complex [PtII(terpy)(py-naphth)](NO3)2(1), incorporating both 2,2′:6′,2′′-terpyridine and 4-N,N′-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.Keywords
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