Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali Radix)
Authors:
- 19 January 2021
- journal article
- review article
- Published by Wiley in Medicinal Research Reviews
- Vol. 41 (4) , 1999-2038
Abstract
Huang‐Qi (Astragali Radix) is an herbal tonic widely used in China and many other countries. It is derived from the roots of Astragalus membranaceus and A. membranaceus var. mongholicus and shows potent cardiovascular protective effects. In this article, we comprehensively reviewed 189 small molecules isolated from the two Astragalus species and discussed the interspecies chemical differences. Moreover, we summarized the pharmacological activities and mechanisms of action of Huang‐Qi and its major bioactive compounds for the treatment of cardiovascular diseases. This review covers 171 references published between February 1983 and March 2020.Keywords
Funding Information
- National Natural Science Foundation of China (81725023, 81891010/81891011, 81921001)
- Natural Science Foundation of Beijing Municipality (JQ18027)
This publication has 112 references indexed in Scilit:
- Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceusMolecules, 2013
- The Critical Role of Astragalus Polysaccharides for the Improvement of PPRAα-Mediated Lipotoxicity in Diabetic CardiomyopathyPLOS ONE, 2012
- Myocardial Ischemia Reperfusion InjurySeminars in Cardiothoracic and Vascular Anesthesia, 2012
- Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential MechanismsOxidative Medicine and Cellular Longevity, 2012
- Huangqiyenins G – J, Four New 9,10‐Secocycloartane (=9,19‐Cyclo‐9,10‐secolanostane) Triterpenoidal Saponins from Astragalus membranaceusBunge LeavesHelvetica Chimica Acta, 2011
- Studies of the Constituents of Astragalus membranaceus BUNGE. III. Structures of Triterpenoidal Glycosides, Huangqiyenins A and B, from the Leaves.Chemical and Pharmaceutical Bulletin, 1997
- Two new cycloartane-type glucosides, mongholicoside I and II, from the aerial part of Astragalus mongholicus bunge.Chemical and Pharmaceutical Bulletin, 1992
- Saponin and sapogenol. XXXVII. Chemical constituents of astragali radix, the root of Astragalus membranaceus Bunge. (4). Astragalosides VII and VIII.Chemical and Pharmaceutical Bulletin, 1983
- Saponin and sapogenol. XXXVI. Chemical constituents of astragali radix, the root of Astragalus membranaceus Bunge. (3). Astragalosides III,V, and VI.Chemical and Pharmaceutical Bulletin, 1983
- Saponin and sapogenol. XXXV. Chemical constituents of astragali radix, the root of Astragalus membranaceus Bunge. (2). Astragalosides I,II and IV, acetylastragaloside I and isoastragalosides I and II.Chemical and Pharmaceutical Bulletin, 1983