C‐Reactive Protein Levels in Patients With Aggressive Periodontitis

Authors:
  • BOBenjamin T. Overstreet
    Benjamin T. Overstreet
  • JRJeffrey D. Rogers
    Jeffrey D. Rogers
  • JCJoseph V. Califano
    Joseph V. Califano
  • HSHarvey A. Schenkein
    Harvey A. Schenkein
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Abstract
Background: Sera from patients with periodontal infections contain elevated levels of C‐reactive protein (CRP) compared to periodontally healthy individuals. Most studies to date have included patients with chronic periodontitis, and few investigators have studied CRP levels in subjects with aggressive periodontitis (AgP). The purpose of this study was to determine the relative levels of serum CRP in AgP patients and periodontally healthy subjects and to examine patients' characteristics that might account for intergroup differences.Methods: Serum samples were collected from 93 patients with generalized AgP (GAgP), from 97 patients with localized AgP (LAgP), and from 91 healthy controls (non‐periodontitis [NP]). Periodontal examination consisted of plaque index, gingival index, probing depth, bleeding index, and attachment loss measurements. Current smoking was assessed by determination of serum cotinine levels by enzyme‐linked immunosorbent assay (ELISA), and serum CRP levels were determined using a high‐sensitivity ELISA assay.Results: The three groups were significantly different from one another (P Conclusions: Patients with AgP have statistically significant elevations in serum CRP levels compared to subjects without periodontitis. Elevated CRP in these subjects might represent a contribution of periodontal infections to systemic inflammation in relatively young individuals.

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