Loading and Release of Ibuprofen in Multi‐ and Monofilament Surgical Sutures

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Abstract
Summary: The preparation of mono‐ and multifilament sutures incorporating ibuprofen as an anti‐inflammatory agent is considered. Poly(p‐dioxanone) monofilament samples can be loaded by a molecular diffusion process using a swelling agent such as dichloromethane. The mechanical properties have been measured and have not shown a significant change for the ibuprofen loaded samples in knot tensile assays. The kinetics of both the loading process and the release in a Sörensen's medium at 37 °C have been investigated. Diffusion coefficients have also been estimated from film and slab poly(p‐dioxanone) samples containing ibuprofen and their release behavior compared to that shown by monofilaments. Release from a coating copolymer based on lactide, ε‐caprolactone and trimethylene carbonate (PLA/PCA/PTMC 10/60/30) has also been studied. This coating solubilizes ibuprofen molecules well and can be used for braided sutures or when a rapid dose of ibuprofen is preferred. magnified image

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