Bmi1 in development and tumorigenesis of the central nervous system
Authors:
- 23 June 2005
- journal article
- review article
- Published by Springer Nature in Journal of Molecular Medicine
- Vol. 83 (8) , 596-600
Abstract
The role of the Polycomb group gene Bmi1 in proliferation control of lymphoid and neuronal progenitors as well as in self-renewal of haematopoietic and neural stem cells has been recently demonstrated. Here we review these recent findings with particular regard to their implications for central nervous system development and tumorigenesis.Keywords
This publication has 26 references indexed in Scilit:
- Diverse mechanisms regulate stem cell self-renewalCurrent Opinion in Cell Biology, 2004
- Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomasNature, 2004
- Therapeutic implications of cancer stem cellsCurrent Opinion in Genetics & Development, 2004
- Cancerous stem cells can arise from pediatric brain tumorsProceedings of the National Academy of Sciences, 2003
- Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferationNature, 2003
- Bmi-1 determines the proliferative capacity of normal and leukaemic stem cellsNature, 2003
- The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expressionBritish Journal of Cancer, 2001
- Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.Genes & Development, 1994
- bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis.1993
- Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus taggingCell, 1991