Prenatal lesioning of vestibular organ by aminoglycosides

Authors:
  • CCCatherine Chappert
    Catherine Chappert
  • CFCaroline Fonta
    Caroline Fonta
  • MIMichel Imbert
    Michel Imbert
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Abstract
The effects of gentamicin administrated to gravid mice on the vestibular hair cells of their offspring were investigated. Scanning electron microscopy showed the effect to be dose-dependent and age-dependent, and there was a different sensitivity to toxicity for each of the three types of vestibular receptors. The destructive action of gentamicin on the vestibule before birth provides a mechanism to study the influence of the vestibular system on the central nervous system throughout its development.