Increased energy expenditure in poorly controlled Type 1 (insulin-dependent) diabetic patients
Authors:
- 1 July 1984
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 27 (1) , 13-16
Abstract
The basal energy expenditure of 10 Type 1 (insulin-dependent) C-peptide-negative diabetic patients (2042±62 kcal/24 h) was found to be significantly higher than the 1774±52kcal/24h predicted from their age, sex and body surface area (pp< 0.01), which matched predicted values. The observed increase in metabolic rate in uncontrolled diabetic patients is associated with increased protein turnover, increased plasma glucagon, but no significant increase in cortisol, growth hormone or triiodothyronine concentrations in plasma. It may be accounted for by the energy cost of protein synthesis, or gluconeogenesis, or possibly increased sympathetic activity. This increased energy expenditure will contribute to the weight loss seen in Type 1 diabetic patients.Keywords
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