OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst
Open Access
- 20 October 2004
- journal article
- patterns and-phenotypes
- Published by Wiley in Developmental Dynamics
- Vol. 231 (4) , 766-774
Abstract
The mammalian inner ear derives from the otocyst. Molecular mechanisms underlying inner ear development are largely unknown. We have isolated a secreted molecule, OC29, from a rat otocyst cDNA library by the signal sequence trap method. OC29 was revealed to be a rat homologue of human WFIKKN. OC29 is preferentially expressed in the developing inner ear and the dorsal neural tube. In the inner ear, the expression of OC29 is first detectable at embryonic day 11.5 (E11.5), broadly in the dorsolateral region of the otocyst, which gives rise to the vestibular organ. At E12.5, the expression of OC29 becomes restricted to the presumptive sensory region, mainly to the BMP4‐positive presumptive cristae, and expression becomes reduced at later stages. These results suggest that OC29 may have a role in the early development of the inner ear sensory organ, particularly in the formation of the cristae of the semicircular canals. Developmental Dynamics 231:766–774, 2004.Keywords
This publication has 46 references indexed in Scilit:
- BMPER, a Novel Endothelial Cell Precursor-Derived Protein, Antagonizes Bone Morphogenetic Protein Signaling and Endothelial Cell DifferentiationMolecular and Cellular Biology, 2003
- Determination of the embryonic inner earJournal of Neurobiology, 2002
- A review of inner ear fate maps and cell lineage studiesJournal of Neurobiology, 2002
- Cloning and expression analysis of the chick DAN gene, an antagonist of the BMP family of growth factorsDevelopmental Dynamics, 2002
- Genetic Patterning of Embryonic Inner Ear DevelopmentActa Oto-Laryngologica, 2000
- Molecular Cloning, Characterization, and Chromosomal Localization of FKBP23, a Novel FK506-Binding Protein with Ca2+-Binding AbilityGenomics, 1998
- Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane ProteinsScience, 1993
- Tissue Interactions and Growth Factors that Control Development of the Inner EarAnnals of the New York Academy of Sciences, 1991
- A simple method for displaying the hydropathic character of a proteinJournal of Molecular Biology, 1982
- The fate mapping of the eleventh and twelfth day mouse otocyst: An in vitro study of the sites of origin of the embryonic inner ear sensory structuresJournal of Morphology, 1978