Interaction of Rheumatoid Factor with Infectious Herpes Simplex Virus-Antibody Complexes
Authors:
- 9 April 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 172 (3979) , 176-177
Abstract
Rheumatoid factor, a human immunoglobulin of the IgM class, failed to attach to herpes simplex virus but did attach to infectious complexes composed of herpes simplex virus and antibody to herpes simplex virus. These newly formed complexes of infectious virus, antiviral antibody, and rheumatoid factor could be neutralized by complement or by antibody to human IgM. The ability of rheumatoid factor to enhance virus neutralization in the presence of complement represents a hitherto unrecognized biological role for rheumatoid factor.Keywords
This publication has 16 references indexed in Scilit:
- COMPLEMENT FIXATION BY A TWO-COMPONENT ANTIBODY SYSTEM: IMMUNOGLOBULIN G AND IMMUNOGLOBULIN M ANTI-GLOBULIN (RHEUMATOID FACTOR)Journal of Experimental Medicine, 1970
- THE PATHOGENESIS OF ALEUTIAN DISEASE OF MINKJournal of Experimental Medicine, 1969
- Immune Complexes in Mice infected neonatally with Moloney Leukaemogenic and Murine Sarcoma VirusesNature, 1969
- Neutralization of Sensitized Virus by the Fourth Component of ComplementScience, 1969
- A SPECIFIC INACTIVATOR OF MAMMALIAN C'4 ISOLATED FROM NURSE SHARK (Ginglymostoma cirratum) SERUMJournal of Experimental Medicine, 1969
- PATHOGENESIS OF CHRONIC DISEASE ASSOCIATED WITH PERSISTENT LYMPHOCYTIC CHORIOMENINGITIS VIRAL INFECTIONJournal of Experimental Medicine, 1969
- Kinetics of neutralization of sensitized herpes simplex virus with antibody fragmentsVirology, 1969
- Aleutian Disease of Mink: Infectious Virus-Antibody Complexes in the Serum.Experimental Biology and Medicine, 1967
- INFECTIOUS VIRUS-ANTIBODY COMPLEX IN THE BLOOD OF CHRONICALLY INFECTED MICEJournal of Experimental Medicine, 1966
- ACTIVITY OF DISSOCIATED AND REASSOCIATED 19S ANTI-γ-GLOBULINSJournal of Experimental Medicine, 1964