Role of Adenovirus Antigens in the Induction of Virus Neutralizing Antibody

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  • LKL. Kjellen
    L. Kjellen
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Abstract
Guinea pig antisera were prepared against purified hexon, penton and fibre antigens of adenovirus type 5. Sera reacting specifically with particular antigens as judged by immunodiffusion, complement fixation and haemagglutination-inhibition tests were assayed for virus neutralizing capacity. The latter was exerted almost exclusively by anti-hexon sera. Type 5 anti-hexon but not anti-fibre sera neutralized type 1 virus provided the serum virus reaction took place at low pH values.