A Study of Magnetic Drug Delivery System Using Bulk High Temperature Superconducting Magnet

Authors:
  • SNShigehiro Nishijima
    Shigehiro Nishijima
  • STShin-Ichi Takeda
    Shin-Ichi Takeda
  • FMFumihito Mishima
    Fumihito Mishima
  • YTYasuhiko Tabata
    Yasuhiko Tabata
  • JJJun-Ichiro Joh
    Jun-Ichiro Joh
  • HIHiroshi Iseki
    Hiroshi Iseki
  • YMYoshihiro Muragaki
    Yoshihiro Muragaki
  • ASAkira Sasaki
    Akira Sasaki
  • KJKubota Jun
    Kubota Jun
  • NSNorihide Saho
    Norihide Saho
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Abstract
A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.

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