Comparative in vitro activity of azithromycin, clarithromycin, erythromycin and lomefloxacin againstMycoplasma pneumoniae, Mycoplasma hominis andUreaplasma urealyticum

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Abstract
The in vitro activity of three macrolides, azithromycin, clarithromycin and erythromycin and a new fluoroquinolone, lomefloxacin, against pathogenic mycoplasma (16 to 18 strains ofMycoplasma pneumoniae, 41 to 77 strains ofMycoplasma hominis, 65 to 104 strains ofUreaplasma urealyticum) was compared. The three macrolides were highly active againstMycoplasma pneumoniae. Clarithromycin was the most active macrolide againstUreaplasma urealyticum whereas azithromycin was somewhat more active than erythromycin againstMycoplasma hominis. Lomefloxacin was moderately active against all three mycoplasma species.

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