Hepatitis C Virus NS5A Binds to the mRNA Cap-binding Eukaryotic Translation Initiation 4F (eIF4F) Complex and Up-regulates Host Translation Initiation Machinery through eIF4E-binding Protein 1 Inactivation
Open Access
- 1 February 2012
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 287 (7) , 5042-5058
Abstract
No abstract availableKeywords
This publication has 77 references indexed in Scilit:
- Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replicationGenes & Development, 2010
- Regulation of Eukaryotic Initiation Factor 4E (eIF4E) Phosphorylation by Mitogen-Activated Protein Kinase Occurs through Modulation of Mnk1-eIF4G InteractionMolecular and Cellular Biology, 2010
- Hepatitis C Virus NS5A Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Contributing to Cell Survival by Disrupting the Interaction between FK506-binding Protein 38 (FKBP38) and mTORJournal of Biological Chemistry, 2010
- Rapamycin-Resistant mTORC1 Kinase Activity Is Required for Herpesvirus ReplicationJournal of Virology, 2010
- The mechanism of eukaryotic translation initiation and principles of its regulationNature Reviews Molecular Cell Biology, 2010
- Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1Proceedings of the National Academy of Sciences, 2010
- MYC Activity Mitigates Response to Rapamycin in Prostate Cancer through Eukaryotic Initiation Factor 4E–Binding Protein 1–Mediated Inhibition of AutophagyCancer Research, 2009
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological TargetsCell, 2009
- Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translationProceedings of the National Academy of Sciences, 2008
- Dissecting eIF4E action in tumorigenesisGenes & Development, 2007