Pd-catalyzed intramolecular C–H activation for the synthesis of fused-1,2,3-triazole quinolines and dihydroquinolines

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Abstract
A Pd-catalyzed, simple, and efficient approach toward structurally diverse fused polycyclic [1,2,3]triazolo[4,5-c]quinoline and 4,5-dihydro-[1,2,3]triazolo[4,5-c]quinoline has been developed. The method is based on intramolecular Pd-catalyzed C–H activation and features operational simplicity, high atom economy, broad substrate scope, excellent yields, and good functional group tolerance. Gram-scale experiments and post-synthetic modifications were performed to extend the synthetic applicability of the proposed methodology and enhance the structural complexity of the obtained derivatives.
Funding Information
  • Università Cattolica del Sacro Cuore (Linea di intervento D.1 2023)
  • Sapienza Università di Roma (Progetti di Ateneo Medi 2023)

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