Promiscuity and diversity in 3-ketosteroid reductases

This publication has 52 references indexed in Scilit:

• Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride
  The Journal of Steroid Biochemistry and Molecular Biology, 2012
• Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo–keto reductase superfamily
  The Journal of Steroid Biochemistry and Molecular Biology, 2012
• Activities of aldo-keto reductase 1 enzymes on two inhaled corticosteroids: Implications for the pharmacological effects of inhaled corticosteroids
  Chemico-Biological Interactions, 2011
• Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)
  Steroids, 2011
• Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer
  The Journal of Steroid Biochemistry and Molecular Biology, 2010
• Human Cytosolic Hydroxysteroid Dehydrogenases of the Aldo-ketoreductase Superfamily Catalyze Reduction of Conjugated Steroids
  Journal of Biological Chemistry, 2009
• Crystal Structure of Human Liver Δ4-3-Ketosteroid 5β-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis
  Journal of Biological Chemistry, 2008
• Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms
  Archives of Biochemistry and Biophysics, 2007
• Identification of the molecular switch that regulates access of 5α-DHT to the androgen receptor
  Molecular and Cellular Endocrinology, 2007
• Multiple Steps Determine the Overall Rate of the Reduction of 5α-Dihydrotestosterone Catalyzed by Human Type 3 3α-Hydroxysteroid Dehydrogenase: Implications for the Elimination of Androgens
  Biochemistry, 2006