CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3
Authors:
Open Access
- 1 January 2021
- journal article
- research article
- Published by Ivyspring International Publisher in Theranostics
- Vol. 11 (6) , 2612-2633
Abstract
Background: Metastasis is the major reason for the high mortality of colorectal cancer (CRC). However, the molecular mechanism underlying CRC metastasis remains unclear. Here, we report a novel role of homeobox B5 (HOXB5), a member of the HOX family, in promoting CRC metastasis.Keywords
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