Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain
Open Access
- 30 October 2019
- journal article
- research article
- Published by Oxford University Press (OUP) in Brain
- Vol. 142 (12) , 3806-3833
Abstract
Inflammatory activation of microglia in the brains of prematurely born infants can lead to permanent neurological sequelae. Van Steenwinckel et al. show that a reduction in microglial Wnt signalling is necessary and sufficient to drive a microglial phenotype causing hypomyelination, and establish the Wnt pathway as a viable therapeutic target.Keywords
Funding Information
- Université Paris Diderot
- Université Sorbonne-Paris-Cité, Investissement d'Avenir (ANR-11-INBS-0011)
- ERA-Net NEURON
- Association Robert Debré, PremUP, Fondation de France
- Fondation pour la Recherche sur le Cerveau
- Fondation des Gueules Cassées, Roger de Spoelberch Foundation, Grace de Monaco Foundation
- Leducq Foundation, Action Medical Research
- Cerebral Palsy Alliance Research Foundation Australia
- Wellcome Trust (WSCR P32674)
- Swedish Research Council (2015-02493)
- Department of Perinatal Imaging and Health, King’s College London
- National Institute for Health Research
- NIHR
- Biomedical Research Centre based at Guy's and St Thomas
- NHS Foundation Trust and King's College London
- Department of Health
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