The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human chromosome 4q
- 1 August 1993
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 4 (4) , 410-414
Abstract
The autosomal Booroola fecundity gene (FecB) mutation in sheep increases ovulation rate and litter size, with associated effects on ovarian physiology and hormone profiles. Analysis of segregation in twelve families (379 female progeny) identified linkage between the mutation, two microsatellite markers (OarAE101 and OarHH55, Zmax >9.0) and epidermal growth factor (EGF) from human chromosome 4q25 (Zmax >3.0). The marker OarAE101 was linked to secreted phosphoprotein 1 (SPP1, which maps to chromosome 4q21–23 in man) in the test pedigrees and independent families (Zmax >9.7). The identification of linkage between the FecB mutation and markers from human chromosome 4q is an important step towards further understanding the control of ovulation rates in mammals.Keywords
This publication has 37 references indexed in Scilit:
- Genetic linkage analysis between protein polymorphisms and the FecB major gene in sheepAnimal Genetics, 1992
- Sheep linkage mapping: restriction fragment length polymorphism detection with heterologous cDNA probesAnimal Genetics, 1992
- Expression of the genes for α inhibin, βA inhibin and follistatin in the ovaries of Booroola ewes which were homozygotes or non-carriers of the fecundity gene FecBJournal of Molecular Endocrinology, 1992
- Physiology and molecular genetics of mutations that increase ovulation rate in sheepEndocrine Reviews, 1992
- Evidence for the Presence of a Major Gene Influencing Ovulation Rate on the X Chromosome of SheepBiology of Reproduction, 1991
- The Booroola F gene mutation in sheep is not located close to the FSH-β geneJournal of Molecular Endocrinology, 1990
- Extraction of DNA from sheep white blood cellsNew Zealand Journal of Agricultural Research, 1990
- Gonadotrophins, fecundity genes and ovarian follicular functionJournal of Steroid Biochemistry, 1987
- Genetic epidemiology of twinning: A population-based studyAmerican Journal of Medical Genetics, 1985
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977