Lung transplantation is an important treatment option for individuals with advanced cystic fibrosis (CF) lung disease. CF outcomes have improved dramatically, particularly since the advent of cystic fibrosis transmembrane conductance regulator (CFTR) modulators. Despite these advances, transplant will likely remain an important consideration for many patients who have disease progression in the coming decades due to intolerance of or lack of access to these novel treatments. Others with CF may require transplantation of extrapulmonary solid organs, most commonly the liver and pancreas. People with CF consistently look to their CF teams for guidance, and there is a need for providers to thus be familiar with lung and other organ transplantation. CF care teams must appropriately counsel their patients on transplant, refer for transplant in a timely manner, and participate in shared care after transplantation to improve the chance of successful outcomes. This chapter reviews important considerations for people with CF before and after lung and other solid organ transplantation.