Occlusion of left atrial appendage affects metabolomic profile: focus on glycolysis, tricarboxylic acid and urea metabolism
Authors:
Open Access
- 20 September 2017
- journal article
- research article
- Published by Springer Nature in Metabolomics
- Vol. 13 (11) , 127
Abstract
Left atrial appendage (LAA) closure (LAAC) by implantation of an occlusion device is an established cardiac intervention to reduce risk of stroke while avoiding intake of oral anticoagulation medication during atrial fibrillation. Cardiac interventions can alter local or systemic gene and protein expression. Effects of LAAC on systemic metabolism have not been studied yet.Keywords
This publication has 31 references indexed in Scilit:
- Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study)Heart Rhythm, 2015
- Improvement in Estimated Glomerular Filtration Rate in Patients with Chronic Kidney Disease Undergoing Catheter Ablation for Atrial FibrillationJournal of Cardiovascular Electrophysiology, 2014
- The cardiac atrial appendage stem cell: a new and promising candidate for myocardial repairCardiovascular Research, 2012
- Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)European Heart Journal, 2010
- Metabolomic profiles delineate potential role for sarcosine in prostate cancer progressionNature, 2009
- Combined Metabolomic and Proteomic Analysis of Human Atrial FibrillationJACC, 2008
- Elimination of the Left Atrial Appendage To Prevent Stroke or Embolism?Chest, 2003
- Regulation of Nitric Oxide Production by Arginine Metabolic EnzymesBiochemical and Biophysical Research Communications, 2000
- Left atrial appendage: structure, function, and role in thromboembolismHeart, 1999
- Assessment of left atrial appendage function by transesophageal echocardiography. Implications for the development of thrombus.Circulation, 1991