The action of acetylcholine on background conductance in frog atrial trabeculae.

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Abstract
The action of acetylcholine (ACh) on membrane potential and currents in frog atrial muscle was studied with a double sucrose gap technique. ACh induces the development of an extra current, outward at the resting potential, which is dependent on the ACh concentration. The preparation does not show any sign of desensitization. The reversal potential of the current induced by ACh is between 0 and 20 mV more negative than the resting potential and behaves as a K electrode. The mechanism of ACh-induced K conductance presents inward going rectification properties. The delayed outward current is not affected by ACh. The evolution of its tail current seems to indicate a process of K accumulation related to the ACh-induced current.

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