Incidence of Meningococcal Disease Before and After Implementation of Quadrivalent Meningococcal Conjugate Vaccine in the United States

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Abstract
Meningococcal disease is a serious bacterial infection caused by Neisseria meningitidis leading to high rates of death and disability.1 In the United States, serogroups B, C, and Y cause most meningococcal infections.2 Although the incidence of meningococcal disease is highest in infants, adolescents and young adults have an increased risk of meningococcal disease as well as the highest rates of oropharyngeal carriage, and thus are considered to be the primary source of N meningitidis transmission to other age groups.3 As a result, adolescents are the primary target group for meningococcal vaccination in the United States.

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