The Association of Goitrous Autoimmune Thyroiditis with HLA‐DR5*

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Abstract
We found HLA‐DR5 to be present among 53% of 40 patients with goitrous autoimmune (Hashimoto's) thyroiditis compared to 26% of 80 controls. No deviations from those expected in the incidences of HLA‐A, B, C antigens were seen. In contrast HLA‐DR3 was increased among 50 patients with atrophic thyroiditis (65%) compared to controls (24%). These findings stress the immunogenetic heterogeneity between the goitrous and atrophic varieties of thyroiditis.

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