Benzo[ a ]pyrene Metabolites: Efficient and Rapid Separation by High-Pressure Liquid Chromatography
Authors:
- 12 April 1974
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 184 (4133) , 169-171
Abstract
High-pressure liquid chromatography can separate eight metabolites of benzo [a] pyrene formed by rat liver microsomes. This method offers major advantages over previous techniques used for the separation of oxygenated polycyclic aromatic hydrocarbons.Keywords
This publication has 15 references indexed in Scilit:
- Gas Chromatographic Assay of Epoxide Hydrase Activity with 3-Methylcholanthrene-11,12-OxideScience, 1973
- Metabolic conversion of benzo[a]pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acidJournal of Medicinal Chemistry, 1973
- Binding of K-region epoxides and other derivatives of benz[a]anthracene and dibenz[a,h]anthracene to DNA, RNA and proteins of transformable cellsChemico-Biological Interactions, 1972
- Epoxides as microsomal metabolites of polycyclic hydrocarbonsFEBS Letters, 1971
- An epoxide is an intermediate in the microsomal metabolism of the chemical carcinogen, dibenz(a,h)anthraceneBiochemical and Biophysical Research Communications, 1971
- Dimethylbenzanthracene Tumorigenesis and Aryl Hydrocarbon Hydroxylase in Mouse Skin: Inhibition by 7,8-BenzoflavoneScience, 1970
- 1,2-Naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene. VBiochemistry, 1970
- The metabolism of 7,12‐dimethylbenz(A)anthracene in cell culturesInternational Journal of Cancer, 1968
- The metabolism of benzo[a]pyrene by rat-liver homogenatesBiochemical Pharmacology, 1967
- Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic AcidNature, 1964