Carbohydrazide Analogues: A Review of Synthesis and Biological Activities
Authors:
- Ebuka Leonard OnyeyilimEOEbuka Leonard Onyeyilim
- Mercy Amarachi EzeokonkwoMEMercy Amarachi Ezeokonkwo
- David Izuchukwu UgwuDUDavid Izuchukwu Ugwu
- Chiamaka Peace UzoewuluCUChiamaka Peace Uzoewulu
- Florence Uchenna EzeFEFlorence Uchenna Eze
- Vivian Ifeoma OkonkwoVOVivian Ifeoma Okonkwo
- Cosmas Chinweike EzeCECosmas Chinweike Eze
- James Anayochukwu EzugwuJEJames Anayochukwu Ezugwu
- 1 March 2022
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Mini-Reviews in Medicinal Chemistry
- Vol. 22 (4) , 661-682
Abstract
: Carbohydrazides and their Schiff bases are important classes of heterocycles that are not only employed in the area of organic chemistry but also have tremendous applications in physical and inorganic chemistry. A series of potentially bioactive compounds containing carbohydrazide functionality and their hydrazone derivatives have been synthesized and screened for antibacterial, anticancer, antifungal and anti-inflammatory, etc. This brief review discloses some synthetic routes to so many reported carbohydrazides, their Schiff bases, their biological activities, and their structure-activity relationship.Keywords
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