Establishment, maintenance, and biological roles of non-CG methylation in plants
Open Access
- 11 October 2019
- journal article
- review article
- Published by Portland Press Ltd. in Essays in Biochemistry
- Vol. 63 (6) , 743-755
Abstract
Cytosine DNA methylation is prevalent throughout eukaryotes and prokaryotes. While most commonly thought of as being localized to dinucleotide CpG sites, non-CG sites can also be modified. Such non-CG methylation is widespread in plants, occurring at trinucleotide CHG and CHH (H = A, T, or C) sequence contexts. The prevalence of non-CG methylation in plants is due to the plant-specific CHROMOMETHYLASE (CMT) and RNA-directed DNA Methylation (RdDM) pathways. These pathways have evolved through multiple rounds of gene duplication and gene loss, generating epigenomic variation both within and between species. They regulate both transposable elements and genes, ensure genome integrity, and ultimately influence development and environmental responses. In these capacities, non-CG methylation influence and shape plant genomes.Keywords
This publication has 142 references indexed in Scilit:
- In Vitro Transcription Activities of Pol IV, Pol V, and RDR2 Reveal Coupling of Pol IV and RDR2 for dsRNA Synthesis in Plant RNA SilencingMolecular Cell, 2012
- Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in PlantsCell, 2012
- Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse GenomeCell, 2012
- Epigenetic contribution to stress adaptation in plantsCurrent Opinion in Plant Biology, 2011
- An Effector of RNA-Directed DNA Methylation in Arabidopsis Is an ARGONAUTE 4- and RNA-Binding ProteinCell, 2009
- RNA‐directed DNA methylation requires an AGO4‐interacting member of the SPT5 elongation factor familyEMBO Reports, 2009
- Epigenetic Reprogramming and Small RNA Silencing of Transposable Elements in PollenCell, 2009
- Subunit Compositions of the RNA-Silencing Enzymes Pol IV and Pol V Reveal Their Origins as Specialized Forms of RNA Polymerase IIMolecular Cell, 2009
- Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent GenesCell, 2008
- The SRA Methyl-Cytosine-Binding Domain Links DNA and Histone MethylationCurrent Biology, 2007