Role of TFEB in Autophagy and the Pathogenesis of Liver Diseases
Author:
Open Access
- 6 May 2022
- journal article
- review article
- Published by MDPI AG in Biomolecules
- Vol. 12 (5) , 672
Abstract
The transcription factor EB (TFEB) is a master regulator of lysosomal function and autophagy. Mechanistic target of rapamycin (mTOR)-mediated phosphorylation on TFEB is known to regulate TFEB subcellular localization and activity at the lysosomal surface. Recent studies have shown that TFEB also plays a critical role in physiological processes such as lipid metabolism, and dysfunction of TFEB has been observed in the pathogenesis of several diseases. Owing to its ability to improve disease status in murine models, TFEB has attracted attention as a therapeutic target for diseases. In this review, we will present the regulation of TFEB and its role in the pathogenesis of liver diseases, particularly non-alcoholic fatty liver disease (NAFLD).Keywords
Funding Information
- LA CaTS Pilot Grant (U54 GM104940)
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