The effect of an innovative thiadiazine-class antibacterial agent on the motility of Vibrio cholerae

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Abstract
Introduction. Vibrio cholerae motility plays a key role in the pathogenesis of cholera, so finding ways to suppress it is a promising approach to combating this infection. Objective: to study the effect of Fluorothiazinone on the motility of V. cholerae. Materials and methods. Flagellar motility was determined in 0.3% agar, with the motility zone measured, in 40 strains V. cholerae El Tor of varying epidemiological significance. The ability of these strains to acquire resistance to Fluorothiazinone was also assessed through repeated subcultures on alkaline agar containing Fluorothiazinone (100 mg/L). Results. A significant decrease in the motility of all studied cultures was observed in the presence of Fluorothiazinone, without the development of resistance. Conclusion. The dose-dependent ability of Fluorothiazinone to reduce the motility of V. cholerae was demonstrated for the first time.

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