Potential Effects of Selenium And N-Acetylcysteine Supplementation in Ameliorating Cardinal Symptoms of Nω-Nitro-L-Arginine Methyl Ester Hydrochloride (L-NAME) Induced Preeclampsia in Wistar Rats
Open Access
- 1 January 2025
- journal article
- Published by National Academy of Sciences of Tajikistan in Reports of Biochemistry and Molecular Biology
- Vol. 13 (4) , 495-506
Abstract
Background: Preeclampsia (PE) is a hypertensive disorder in pregnancy affecting multiple organ systems. This study hypothesized that oxidative stress and inflammatory responses contribute to the pathogenesis of Preeclampsia, and that selenium and N-acetylcysteine (NAC) could mitigate these effects. Methods: The study was initiated after approval from the Institutional Animal Ethics Committee. ...Keywords
This publication has 34 references indexed in Scilit:
- Rutin and selenium nanoparticles protected against STZ-induced diabetic nephropathy in rats through downregulating Jak-2/Stat3 pathway and upregulating Nrf-2/HO-1 pathwayEuropean Journal of Pharmacology, 2022
- The determinant role of IL-6 in the establishment of inflammation leading to spontaneous preterm birthCytokine & Growth Factor Reviews, 2021
- N-Acetyl-l-cysteine and aminooxyacetic acid differentially modulate trichloroethylene reproductive toxicity via metabolism in Wistar ratsArchives of Toxicology, 2021
- The effects of N-Acetylcysteine on serum level of inflammatory biomarkers in adults. Findings from a systematic review and meta-analysis of randomized clinical trialsCytokine, 2020
- N-Acetylcysteine Resolves Placental Inflammatory-Vasculopathic Changes in Mice Consuming a High-Fat DietThe American Journal of Pathology, 2019
- Association of pro‐ and anti‐inflammatory cytokines in preeclampsiaJournal of Clinical Laboratory Analysis, 2019
- Preeclampsia: Syndrome or Disease?Current Hypertension Reports, 2015
- Measurement of the total antioxidant response in preeclampsia with a novel automated methodEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2005
- N-acetylcysteine restores nitric oxide–mediated effects in the fetoplacental circulation of preeclamptic patientsAmerican Journal of Obstetrics and Gynecology, 2004
- Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric methodClinica Chimica Acta, 1978