Health Effects and Mechanisms of Inulin Action in Human Metabolism

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Abstract
Inulin is a plant polysaccharide which, due to its chemical structure, is not digestible by human gut enzymes but by some bacteria of the human microbiota, acting as a prebiotic. Consequently, inulin consumption has been associated with changes in the composition of the intestinal microbiota related to an improvement of the metabolic state, counteracting different obesity-related disturbances. However, the specific mechanisms of action, including bacterial changes, are not exactly known. Here, a bibliographic review was carried out to study the main effects of inulin on human metabolic health, with a special focus on the mechanisms of action of this prebiotic. Inulin supplementation contributes to body weight and BMI control, reduces blood glucose levels, improves insulin sensitivity, and reduces inflammation markers, mainly through the selective favoring of short-chain fatty acid (SCFA)-producer species from the genera Bifidobacterium and Anaerostipes. These SCFAs have been shown to ameliorate glucose metabolism and decrease hepatic lipogenesis, reduce inflammation, modulate immune activity, and improve anthropometric parameters such as body weight or BMI. In conclusion, the studies collected suggest that inulin intake produces positive metabolic effects through the improvement of the intestinal microbiota and through the metabolites produced by its fermentation.
Funding Information
  • Gobierno de Navarra (0011-1383-2022-000000 [PARABIOTICS], 0011-1411-2021-000100 [ALISSEC], PID2022-141766OB-I00, CB12/03/30002)
  • Ministerio de Ciencia e Innovación (0011-1383-2022-000000 [PARABIOTICS], 0011-1411-2021-000100 [ALISSEC], PID2022-141766OB-I00, CB12/03/30002)
  • Center for International Business Education and Research, University of Illinois at Urbana-Champaign (0011-1383-2022-000000 [PARABIOTICS], 0011-1411-2021-000100 [ALISSEC], PID2022-141766OB-I00, CB12/03/30002)

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