Reagentless Oxidative Folding of Disulfide‐Rich Peptides Catalyzed by an Intramolecular Diselenide
Authors:
- 27 March 2012
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 51 (23) , 5580-5584
Abstract
Building bridges: In cysteine‐rich peptides, diselenides can be used as a proxy for disulfide bridges as the energetic preference for SeSe bonds over mixed SeS bonds simplifies folding (see picture). An intramolecular diselenide bond efficiently catalyzes the oxidative folding of selenopeptide analogues of conotoxins, and serves as a reagentless method to accelerate formation of various native disulfide bridging patterns.Keywords
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