Empirical bayes analysis of sequencing-based transcriptional profiling without replicates
Open Access
- 16 November 2010
- journal article
- Published by Springer Nature in BMC Bioinformatics
- Vol. 11 (1) , 564
Abstract
Recent technological advancements have made high throughput sequencing an increasingly popular approach for transcriptome analysis. Advantages of sequencing-based transcriptional profiling over microarrays have been reported, including lower technical variability. However, advances in technology do not remove biological variation between replicates and this variation is often neglected in many analyses.Keywords
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