Cobalt‐Catalyzed Oxidative Isocyanide Insertion to Amine‐Based Bisnucleophiles: Diverse Synthesis of Substituted 2‐Aminobenzimidazoles, 2‐Aminobenzothiazoles, and 2‐Aminobenzoxazoles
- 22 March 2013
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 19 (19) , 5850-5853
Abstract
Cobalt catalysis: Synthesis of substituted 2‐aminobenzimidazoles, 2‐aminobenzothiazoles, and 2‐aminobenzoxazoles was achieved by using cobalt(II) acetate catalyzed isocyanide insertion to o‐diaminobenzene, 2‐aminobenzenethiol, and 2‐aminophenol derivatives in 1,4‐dioxane (see scheme). It was found that the reaction proceeded efficiently to give the desired products in up to 95 % isolated yields by CN and CS (O, N) formation in a single step.Keywords
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