Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
Authors:
- Christopher ColecloughCCChristopher Coleclough
- Robert P. PerryRPRobert P. Perry
- Klaus KarjalainenKKKlaus Karjalainen
- Martin WeigertMWMartin Weigert
- 1 April 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 290 (5805) , 372-378
Abstract
A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.Keywords
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