Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells
Open Access
- 10 November 2021
- Vol. 24 (12) , 103412
Abstract
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Funding Information
- Open Philanthropy Project
This publication has 76 references indexed in Scilit:
- Hsp90 Inhibitors Are Efficacious against Kaposi Sarcoma by Enhancing the Degradation of the Essential Viral Gene LANA, of the Viral Co-Receptor EphA2 as well as Other Client ProteinsPLOS Pathogens, 2012
- STAR: ultrafast universal RNA-seq alignerBioinformatics, 2012
- Fiji: an open-source platform for biological-image analysisNature Methods, 2012
- Broad action of Hsp90 as a host chaperone required for viral replicationBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
- Ensembl Genomes: an integrative resource for genome-scale data from non-vertebrate speciesNucleic Acids Research, 2011
- A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and LymphomasClinical Cancer Research, 2011
- SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERKBlood, 2009
- Heat Shock Protein 90 Inhibitors Prolong Survival, Attenuate Inflammation, and Reduce Lung Injury in Murine SepsisAmerican Journal of Respiratory and Critical Care Medicine, 2007
- Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistanceGenes & Development, 2007
- Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction NetworksGenome Research, 2003