Resistance to and synthesis of the antibiotic mupirocin
Authors:
- Joanne HothersallJHJoanne Hothersall
- Christine L. WillisCWChristine L. Willis
- Thomas J. SimpsonTSThomas J. Simpson
- 1 March 2010
- journal article
- review article
- Published by Springer Nature in Nature Reviews Microbiology
- Vol. 8 (4) , 281-289
Abstract
Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections. Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes. Mupirocin biosynthesis is carried out by a combination of type I multifunctional polyketide synthases and tailoring enzymes encoded in a 75 kb gene cluster. Chemical synthesis has also been achieved. This knowledge should allow the synthesis of new and modified antibiotics for the future.Keywords
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