HLA‐A, B, C, D, DR Antigens and Primed Lymphocyte Typing (PLT) Defined DP‐antigens in Juvenile Chronic Arthritis

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Abstract
A total of 48 patients with juvenile chronic arthritis (JCA) were typed for HLA‐A, ‐B, ‐C, ‐D and ‐DR antigens and 36 patients were also typed for HLA‐D/DR associated “DP”‐antigens with the primed lymphocyte typing technique. In the total group of patients, we found increased frequencies of HLA‐B27, HLA‐Dw/DP5 and HLA‐Dw/DP8, and decreased frequencies of HLA‐Dw/‐DR/DP2. The increased frequencies of HLA‐Dw/DP8 and the decreased frequencies of HLA‐Dw/‐DR/DP2 were primarily found among patients with persistent pauciarticular arthritis. The frequencies of HLA‐Dw/‐DR/DP4 were increased in patients with polyarticular arthritis. The frequencies of HLA‐B27 and ‐Dw/DP5 were increased in both pauciarticular and polyarticular arthritis.The results indicate (i) that genetic factors controlled by HLA confer susceptibility and/or resistance to JCA, and (ii) that the clinical subdivision of JCA into pauciarticular and polyarticular JCA can be supported by the presence of different genetic markers (HLA‐antigens) in the two groups of JCA‐patients.If these data can be confirmed HLA‐D, ‐DR or DP typing may be of value in the prognostic evaluation of patients with pauciarticular onset JCA.

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