An enzymatic basis for Lewis blood Types in man
Authors:
- Evelyn F. GrollmanEGEvelyn F. Grollman
- Akira KobataAKAkira Kobata
- Victor GinsburgVGVictor Ginsburg
Open Access
- 1 August 1969
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 48 (8) , 1489-1494
Abstract
Milk from women with blood type Le(a+) or Le(b+) contains a specific fucosyltransferase not found in the milk of women with blood type Le(a- b-). The enzyme, a guanosine diphosphate L-fucose: N-acetyl-β-D-glucosaminylsaccharide α-4-L-fucosyltransferase is apparently required for the synthesis of the structural determinants of Lea and Leb specificity, both of which contain fucose in an α-1,4 linkage to N-acetylglucosamine. The same enzyme is also involved in the synthesis of milk oligosaccharides, as two oligosaccharides which contain this linkage are absent from the milk of women with Le(a- b-) blood type.Keywords
This publication has 17 references indexed in Scilit:
- Oligosaccharides of human milkArchives of Biochemistry and Biophysics, 1969
- Immunochemical studies on blood groups. XXXVIII. Structures and activities of oligosaccharides produced by alkaline degradation of blood-group Lewisa substance. Proposed structure of the carbohydrate chains of human blood-group A,B,H,Lea, and Leb substancesBiochemistry, 1968
- An enzymatic basis for blood type B in humansBiochemical and Biophysical Research Communications, 1968
- An enzymatic basis for secretor status and blood group substance specificity in humans.Proceedings of the National Academy of Sciences, 1968
- An enzymic basis for blood type A in humansArchives of Biochemistry and Biophysics, 1968
- Molecular and Genetic Aspects of Human Blood-group Leb SpecificityNature, 1967
- Correlation between secretor status and the occurrence of 2′-fucosyllactose in human milkBiochemical and Biophysical Research Communications, 1967
- Isolation of a Serologically Active, Fucose-Containing, Trisaccharide From Human Blood-Group Lea SubstanceNature, 1964
- Further Observations on the Inhibition of Blood‐Group Specific Serological Reactions by Simple Sugars of Known StructureVox Sanguinis, 1962
- Possible Genetical Pathways for the Biosynthesis of Blood Group MucopolysaccharidesVox Sanguinis, 1959