Immunological Enhancement into Mice Small Intestinal Tissue Morphology and Immunohistochemistry of L-Arginine-Assisted Silkworm Pupae Protein as an Enteral Nutrition Preparation

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Abstract
Diabetic enteropathy is one of the common complications in people with diabetes, and one of its symptoms, excessive diarrhea, may cause inflammation of the intestines. However, the ability of L-Arginine to ease these inflammatory conditions when present in nutritional preparations has not been fully explored. Here we report a special medical purpose formulas improve the characteristics of diabetic intestinal inflammation through nutrient modulating effects and nutritional efficacy, as well as L-arginine (L-arginine, L-arg) enhances the immunomodulatory effects of special medical purpose formulas for diabetes mellitus. We utilized an oxidative stress model of small intestinal epithelial cells induced by high glucose and an inflammation model of the small intestine triggered by lipopolysaccharide in mice. The aim was to further investigate the protective effects of L-arginine and enteral nutritional preparations derived from silkworm chrysalis protein components on the intestinal tract. This research seeks to establish a theoretical foundation for understanding how L-arginine and these nutritional preparations regulate intestinal inflammation in vivo.

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