BIOAVAILABILITY AND PHARMACOKINETICS OF D-PENICILLAMINE

Authors:
  • WKWR KUKOVETZ
    WR KUKOVETZ
  • EBE BEUBLER
    E BEUBLER
  • FKF KREUZIG
    F KREUZIG
  • AMAJ MORITZ
    AJ MORITZ
  • GNG NIRNBERGER
    G NIRNBERGER
  • LWL WERNERBREITENECKER
    L WERNERBREITENECKER
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  • 1 January 1983
    • journal article
    • research article
    • Vol. 10  (1) , 90-94
    • PMID:6842492
Abstract
The absolute and the relative bioavailability of D-penicillamine [an antiinflammatory drug] available from different dosage forms and products, was studied in 10 healthy volunteers. Plasma levels and urine excretion of D-penicillamine were determined up to 8 h after administration by high performance liquid chromatography after i.v. administration of 250 mg and after oral administration of 250 mg (2 products) and 150 mg (1 product) D-penicillamine. The absolute bioavailability on oral administration was 50-70%. No statistical difference was found between the relative bioavailabilities of the diffeent dosage forms tested.