Brief Communication: Synergistic Effects of Benzo[alpyrene and Diethylnitrosamine on Respiratory Carcinogenesis in Hamsters2

Authors:
  • RMRuggero Montesano
    Ruggero Montesano
  • AFAlessandro Ferrero
    Alessandro Ferrero
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Abstract
Combined treatment of hamsters with a loweffect dose schedule of benzo[a]pyrene plus ferric oxide given intratracheally, followed by a low dose of diethylnitrosamine given systemically, resulted in a synergistic tumor response. Squamous cell carcinomas of the tracheobronchial tract were observed only in the group receiving combined treatment; administration of single carcinogens did not cause similar tumors.