Amino Acids and Peptides; 60.1Synthesis of Biologically Active Cyclopeptides; 10. Synthesis of 16 Structural Isomers of Dolastatin 3; II:2Synthesis of the Linear Educts and the Cyclopeptides

Authors:
  • USUlrich Schmidt
    Ulrich Schmidt
  • RURoland Utz
    Roland Utz
  • ALAlbrecht Lieberknecht
    Albrecht Lieberknecht
  • HGHelmut Griesser
    Helmut Griesser
  • BPBernd Potzolli
    Bernd Potzolli
  • JBJohanna Bahr
    Johanna Bahr
  • KWKarin Wagner
    Karin Wagner
  • PFPeter Fischer
    Peter Fischer
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Abstract
Sixteen isomers of the cancerostatic cyclopeptide Dolastatin 3 of marine origin are synthesized. The proposed structure of Dolastatin 3 is proved to be not correct.