BovineNK-lysin: Copy number variation and functional diversification

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Abstract
Significance: The cattle genome contains expanded families of several genes involved in innate immunity. A single copy of theNK-lysingene is annotated in the genomes of most mammals, including humans, but this study identified a family ofNK-lysingenes in cattle consisting of four functional members. Although this family mirrors the numerical expansion of other immune-related genes, including interferons, defensins, and cathelicidins, in the cattle genome, we also see a diversification of function exhibited by differential tissue expression in the gene family. The current state of this site in the bovine genome appears to capture the evolutionary transition from copy number variation to the fixation of novel gene function within a segmentally duplicated region.
Funding Information
  • USDA | National Institute of Food and Agriculture (201 1-68004 30367)
  • USDA | National Institute of Food and Agriculture (201 1-68004 30367)

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